PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

Title: Lactobacillus casei strain Shirota protects against non-alcoholic steatohepatitis

33 34 Gut microbiota alterations are 35 associated with various disorders. In 36 this study, gut microbiota changes were 37 investigated in a methionine-choline 38 deficient (MCD) diet-induced 39 non-alcoholic steatohepatitis (NASH) 40 rodent model, and the effects of 41 administering Lactobacillus casei strain 42 Shirota (LcS) on the development of 43 NASH were also investigated. Mice 44 were ...

Non-alcoholic steatohepatitis

[Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis].

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome. Since the prevalence of obesity and consequently of the metabolic syndrome is steadily increasing, the different types of NAFLD are nowadays the most common cause of liver injury in North America. The development of NASH and fatty liver cirrhosis occurs af...

Non-alcoholic steatohepatitis in children.

Non-alcoholic steatohepatitis (NASH) is an important liver disease in children; it can cause cirrhosis in children. The disease mechanism involves hepatic insulin resistance with hyperinsulinemia and changes in certain adipocytokines and inflammatory mediators. The differential diagnosis of childhood NASH includes metabolic disorders, drug hepatotoxicity, and alcoholic hepatitis in adolescent p...

Glycine protects against high sucrose and high fat-induced non-alcoholic steatohepatitis in rats

We set out to explore the hypothesis that glycine attenuates non-alcoholic steatohepatitis (NASH) in rats and the possible mechanism by which is it does. Male Sprague-Dawley (SD) rats were fed a diet containing high fat and high sucrose (HSHF) for 24 weeks to induce NASH. Blood and liver tissues were sampled at selected time points throughout the study. Compared with control animals, the conten...